Assays for T Cell Function
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چکیده
Cytotoxic T lymphocytes (CTL) kill target cells on the basis of cell-surface antigen recognition and are important in the host response to tumors, transplants, and viruses. CTL react with a wide variety of antigens including minor and major histocompatibility alloantigens and antigens expressed by syngeneic cells, such as from haptens, tumorassociated products, and viruses. CTL are generated by precursor T lymphocytes (CTLp) following stimulation by specific antigens carried on “stimulator” cells in the presence of products of accessory and helper T cells (UNIT 3.12; Singer et al., 1984). In principle, any cell type can be used as targets for measuring CTL activity, although activated cells such as lymphoblasts, tissue culture cells, or tumor cells have proven to be best.
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تاریخ انتشار 2006